First layer / callibration issue (Prusa i3 - Slic3r)

Hello, I am in the process of tuning my newly built Prusa i3 and I have some issue finding the right parameters to tweak in order to fix some issues with the infill of my first layers. I am using Repetier firmware/host and Slic3r 0.9.10b. The basic calibration seams quite ok and I am getting very u

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