Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts, Malaria Journal

This paper examines the far-reaching implications of Triple Artemisinin-Based Combination Therapy (TACT) in the global battle against malaria. Artemisinin-Based Combination Therapy (ACT) is recognized for its cost-effectiveness, lower likelihood of adverse events, and widespread acceptance by patients and healthcare providers. However, TACT introduces novel dimensions to the fight against malaria that make them a superior choice in several aspects. TACT has been demonstrated to address resistance, offer a broader spectrum of action, reduce the risk of treatment failure, and can be tailored to meet regional needs, strengthening the global effort to combat malaria. However, maximizing these benefits of TACT depends on accessibility, particularly in resource-limited regions where malaria is most prevalent. Collaborative efforts among stakeholders, sustainable pricing strategies, efficient supply chains, and public–private partnerships are essential to ensure that TACT reaches needy populations. Moreover, dispelling prevalent malaria myths through health education campaigns is critical in this endeavour. The paper underscores the significance of collaborative initiatives and partnerships among governments, international organizations, research institutions, acadaemia, pharmaceutical companies, and local communities. Together, these efforts can pave the way for the acceptance, adoption, and success of TACT, ultimately advancing the global goal of a malaria-free world.

Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite - ScienceDirect

Malaria Elimination and Eradication - Major Infectious Diseases - NCBI Bookshelf

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial - ScienceDirect

Expert perspectives on the introduction of Triple Artemisinin-based Combination Therapies (TACTs) in Southeast Asia: a Delphi study, BMC Public Health

Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts, Malaria Journal

Enhancing the antimalarial activity of artesunate

PDF) Antimalarial Drug Resistance and Implications for the WHO Global Technical Strategy

To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?

WWARN (@WWARN) / X

Preventing antimalarial drug resistance with triple artemisinin-based combination therapies

Treatment definitions for uncomplicated malaria patients. ACT

Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda